Sci-Fi

Sci-Fi themed games are games that are characteristic of science fiction literature; the narrative is dependent on the impact of scientific discoveries that do not yet exist in reality. Some games, such as those in the Half-Life series and Unreal series take place in a sci-fi universe that was created specifically for the purpose of the games. Others may take place in existing sci-fi universes, such as licensed Star Wars games. Common elements of sci-fi themed games include futuristic settings, high-tech items and weapons, and alien characters.

Portal

Portal is a Source-engine puzzle game. Players use a first-person perspective to explore a three-dimensional environment that is broken up into a series of levels. The only device available to the player is a portal-placement gun that is used to solve the puzzles. Players can place up to two portals that can then transport the player (or anything else) through them.Portal is a puzzle-lite game with an emphasis on faster replays and conditional achievements.

Quake

Quake is an FPS from iD Software. You play as a grunt who must travel to a variety of worlds through interdimensional portals and destroy a Lovecraftian horror and hundreds of minions before they can locate and overrun earth. Dark Places is a source port that has various enhancements over the official versions.
It may not be as impressive graphically as say, Tenebrae, but this port is the widescreen king of source ports, so it gets the honors here. Dark Places can be downloaded here (original Quake data is required and not included) http://www.icculus.org/twilight/darkplaces/

Scrapland

Players control D-Tritus as he makes his way around the robot city of Chimera. The two main game modes are on foot and ship. D-Tritus gains the ability to "overwrite" other characters in the game and take their place. This allows D-Tritus to masquerade as other characters and use their unique abilities. These abilities include flight, weaponry, theft, and burping. Players can customize their ships with bigger engines or more firepower depending on their playing styles.

Enemy Territory: Quake Wars

Enemy Territory - QUAKE Wars is a team based FPS from ID Software.Game play is similar to Battlefield 2142.This game also has G15 Keyboard support.

Freelancer

Freelancer is a space trading and combat simulation video game developed by Digital Anvil and published by Microsoft Game Studios. It is a chronological sequel to Digital Anvil's Starlancer, a combat flight simulator released in 2000. The game was initially announced by Chris Roberts in 1999, and following many production schedule mishaps and a buyout of Digital Anvil by Microsoft, it was eventually released in March 2003.

Lost Planet: Extreme Condition

Rescued from a veil of ice with only fragments of memory, Wayne Holden struggles to recover his past on a blizzard-ridden world swarming with deadly aliens. With only treacherous Snow Pirates and the mysterious NEVEC Corporation remaining, can anyone be trusted or is everything lost?

Turok: Evolution

Turok: Evolution is a prequel that takes us back to the origins of the Turok lineage. In the beginning of the game, we see our hero, Tal'Set, fighting his nemesis Captain Tobias Bruckner in 1886 Texas. During the battle, a rift between their world and the Lost Lands opens and Tal'Set is sucked into it. Tal'Set, injured and near death, is nursed back to health by the natives of the River Village, a colony in hiding from the Lost Land's greatest threat: the Lord Tyrannus and his reptilian hordes. Tal'Set becomes a reluctant participant in the brutal war that is raging in the Lost Land.

Wolfenstein 3D

Wolfenstein 3D is a seminal first-person shooter game first released in 1992, pitting the player, a captured American spy, against a horde of WWII-era Nazis ensconced within Castle Wolfenstein. It is widely regarded by critics and game journalists as having helped popularize the genre on the PC, and having established the basic run-and-gun archetype for subsequent FPS games.

Sid Meier's Alien Crossfire

Sid Meier's Alien Crossfire is the expansion pack to Sid Meier's Alpha Centauri, a sci-fi themed turn based strategy game. It depicts human colonists of several different factions attempting to populate a planet in the Alpha Centauri system, struggling to survive the planet's harsh conditions, building new cities, discovering new technologies, and often clashing with eachother.

Duke Nukem: Manhattan Project

Duke Nukem: Manhattan Project is a side-scrolling run and gun computer game developed by Sunstorm Interactive.