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Warhammer Online: Age of Reckoning is the popular MMO from from Mythic, set in the Warhammer universe.

SW is a snowboard game with multiple challenges to choose from in open environments, not unlike the late Tony Hawk's Pro Skater series' most recent titles. The Scimitar engine (Assassin's Creed, Prince of Persia 2008) supposedly allows the gameplay to rely solely on physics whereas most "board" games are animation-based. A more obvious feature though is that you can control your avatar through some half-pipe fun during loading times, something AC's Altayr probably misses terribly.

Multiplayer take on Darwinia. Indie game darling "Darwinia" realized in multi-player fashion.

A "remote cousin" of the Heroes of Might & Magic series, King's Bounty : The Legend combines turn-based battles and real-time exploration in a lenghty singleplayer campaign.

Titan Quest is an action RPG by THQ, in the vein of Diablo II. The game is in the historical fantasy genre. Titan Quest is a 3D 'hack and slash' (acton RPG) featuring monsters inspired by ancient mythologies. It has gorgeous graphics, day/night cycle, ragdoll animations, WYSIWYG loot system - and of course, heaps of equipment to collect.
Immortal Throne adds in a whole new chapter (all-new places, quests, monsters and loot), a new mastery with its unique skills, and an array of other new gameplay elements.

WOW is the blockbuster MMO from from Blizzard, set in their Warcraft universe. I did this DR the same week Wrath of the Lich King came out, so this could be considered the WotLK client.

This DR is out of date for the current state of the game (June 2014). Please see the entry for Pandaria.

Dead Space is a third-person survival horror-action video game, developed by EA Redwood Shores for PlayStation 3, Xbox 360, and Microsoft Windows. The player takes on the role of an engineer named Isaac Clarke, who battles a polymorphic, virus-like, alien infestation called the 'Corruption', which turns humans into grotesque alien monsters called 'Necromorphs',on board a stricken interstellar mining ship.

Left 4 Dead is a multiplayer first person shooter from Valve, inspired by recent "zombie apocalypse" movies such as 28 Days Later and I Am Legend. You and three other players must cooperate to progress through a series of environments while fending off an unending onslaught of virus-infected ghouls.

Aquadelic GT is a motorboat racing game with crazy weapons and power-ups. It features a mission-based campaign mode that lets players roam freely around various locations, enter races or complete taxi/delivery tasks to earn cash & reputation.
Also known as Power Boat GT.