Space

Osiris: New Dawn

The year is 2046 and mankind’s discovery of near-lightspeed fold engine propulsion has empowered mankind's Osiris expeditionary missions to the Gliese 581 system. You are the second colonization team sent by the U.N.E. (United Nations of Earth) to study potential habitable planets when your spacecraft malfunctions braking from light speed, forcing an emergency landing on the planet’s surface.

Fractured Space

Fractured Space is a competitive 5-v-5 tactical space battle game fought over five sectors. Brought to life in the stunning Unreal Engine 4, giants of interstellar conflict fight in spectacular close quarter battles for dominance.
Epic Space Battles
Fractured Space’s team-based 5v5 battles hinge on teamwork. Those who can strategise and work together to dominate the battlefield’s objectives will take the enemy base, and victory. Unity is strength.

Offworld Trading Company

From the lead designer of Civilization IV comes a new kind of strategy game: Offworld Trading Company, an economic strategy game.

Mars has been colonized and has invited you to lend a hand to make sure the new colony has a shot at success. But you're not the only one that's been invited, other business rivals are here as well and they have no qualms about playing dirty to gain the choicest territories on the Martian surface and driving their competitors out of business.

X Rebirth

X: Rebirth is set in the Albion space system which was established in X³: Albion Prelude. The player takes the role of Ren Utani who discovers the legendary space ship Albion Skunk and, together with his co-pilot Yisha, gets involved in the faction war between the governing Pultrach Mining Corporation and the Heart of Albion rebels. The campaign mostly serves as introduction to the game elements as the game's focus is still on player freedom.

Sid Meier's Starships

Sid Meier's Starships is a turn-based strategy video game developed by Firaxis Games and published by 2K Games. The game is a stand-alone title but shares the same universe as Civilization: Beyond Earth, putting the player in control of a fleet of space-faring craft. The player will use the fleet to explore the galaxy, meeting other human and alien forces, and dealing with problems through a combination of military, diplomatic, and other strategic options. Spacecraft in the fleet can be highly customized for meeting certain goals.

Elite: Dangerous

"Take control of your own starship in a cutthroat galaxy. Elite: Dangerous brings gaming’s original open world adventure into the modern generation with a connected galaxy, evolving narrative and the entirety of the Milky Way re-created at its full galactic proportions."

Elite: Dangerous is a space simulator game.

StarDrive 2

StarDrive 2 is the sequel to the 4x strategy game StarDrive. In addition to the strategic map now being turn-based (while retaining real-time combat), the game features turn-based ground combat, heroes to command your fleets and improve your colonies, a streamlined ship designer, and more. Explore through a larger, more expansive universe with even more races to encounter, secrets to find, and wars to be wages on both the ground and in space!

Space Colony

In Space Colony HD you must build a base for your ragtag crew, which includes the lovely Venus Jones, Scandinavian biker Stig Svensson, cybernetics expert Mr. Zhang, rowdy barfly Tami and former chicken farmer Billy-Bob Perkins. Keeping your crew happy is tough when they’re so different, but you also have to keep them alive! Maintaining oxygen levels, productivity and defending against hostile alien threats is your responsibility. - official website

Star Citizen

Star Citizen is an upcoming space trading and combat simulator video game for the PC Platform. Star Citizen will consist of two main elements: a persistent world massively multiplayer online game mixing elements of 1st person space combat and interstellar trade (known as Star Citizen) and a branching single-player and drop-in co-operative multiplayer campaign (known as Squadron 42), together with customizable private server components. (Source: Wikipedia)

Star Citizen is currently in development with an estimated release date in Q4 2014. Star Citizen is being entirely crowd funded.

Space Rangers HD: A War Apart

Space Rangers HD: A War Apart remasters and expands the world of the cult classic Space Rangers 2. The game is developed by the SNK-Games team in close cooperation with fans of the series.