Ingame: windowed, 1920x1080, close. Regedit: HKEY_CURRENT_USER\Software\ inXile\Wasteland2\Resolution_h2981718891 (1920x1080) = yours w border. ShiftWindow (+ border = borderless) at inXile logo, close game & restart (only do 1st time. Corrects menu, off-target, & graphic anomaly). ShiftWindow.
(PLP screenshot with bezel effect)
View guide for general help with the instructions.