Project cost and required space aside, I think you may have a problem throwing 180-degree or larger fields of view at sims. Most rendering engines aren't set up to provide this much view all at once (although you can turn your virtual head), and thus sims may choke in this situation.
What title(s) do you plan on using?
I'm coming at this a bit backwards. I am starting with a 20 foot long section of real F-84F and working the project from there. As an F-84F isn't exactly an aircraft that people fly much in flight sims I'll probably have to implement my own F-84F add-on with whatever I use. Sure, Alphasim has an old F-84F freeware, but the instrument planel layout is different than my aircraft and a few other issues are there too.
Undecided at this point. It's too early in my simpit design to definitively say. Possibly DCS: A-10, FighterOps and FSX. Most of the build cost on this is projector cost. That's why I'm selling my 3 current projectors and getting 3 new short-throw ones. As is, I could do a triple-projector setup right now, but I want to eventually do 5 projector and not have to use an ungodly large room for it. Throw distance is playing a major role in this design so far. I might just go 5870 but then do the projection by designating the front screens as an SLS single area but projector 4 and 5 as independent projector cameras in-game. I am aware of 3d engines simply messing up over 180 degrees and I'll have to account for that also.