Game is only 16:9 natively. For removing black bars on 16:10 and 4:3 etc, use files available on PC Gaming Wiki [The fix doesn't work anymore with latest update] and then to remove the vignette, use files available on PC Gaming Wiki
-By default, helifax's fix will force Pre Rendered frames to 1 and cannot be changed via Nvidia Drivers [It reverts back to 1]. To fix this, remove the following lines from d3dx.ini:
; Max Pre-rendered Frames
0x7BA09E = 0x00000001
; Power State: Max Performance
0x1057EB71 = 0x00000001
Another way to disable vignette is by using praydog's RE2 Mod Framework
Extract dinput8.dll to the folder that contains the exe file of the game.
While in game, a menu will pop up [or press insert key to open if it doesn't show up] and then disable vignette [tick the checkbox]. Settings remains saved on the current version, so you don't have to disable it every time.
Known issues with removing vignette with mod framework:
-Lighting glitch. Volumetric lighting becomes invisible if the only thing behind the lighting is the sky which causes serious clipping effect and looks ugly.